Comparison of Esketamine and Sevoflurane on Emergence Agitation

• Status: Recruiting
• Trial end date: 2022-05-17
• Target enrollment: 0
• Participant gender: All

Summary

Emergence agitation is the most common reason for post-anesthesia care unit delay. Sevoflurane is used frequently inhalational anaesthetic agent to provide pediatric anaesthesia because of the nonirritant nature. It has been successfully used for keeping spontaneous breathing without tracheal intubation. However, sevoflurane may cause emergence agitation as the incidence varied from 10%-80%. Although there are many sedative agents to reduce its incidence, such as propofol, midazolam, a2 adrenergic receptor agonists and ketamine, the efficacy remains limited.

Ketamine, a neuroleptic anesthetic agent, contains two optical isomers, s(+)-ketamine (esketamine) and R(-)-ketamine. Esketamine is a right-handed split of ketamine, which has enhanced analgesic potency and lower incidence of psychotropic side effects compared to ketamine. It stimulate breathing due to N-Methyl-D-Aspartate receptor blockade, and could even effectively countered remifentanil-induced respiratory depression. The investigators compared the effectiveness of esketamine and sevoflurane in reducing the incidence of emergence agitation after painless ophthalmological procedure in pediatric patients.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Eye & ENT Hospital of Fudan University
• Treatments: Esketamine; Ketamine; Sevoflurane

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists physical status 1-2

• required to remove the stitches by microscope after corneal surgeries

Exclusion Criteria:

• psychiatric disorders

• cardiovascular disorders

• glaucoma

• contraindications to nasal intubation