Comparison of Esketamine-Propofol and Fentanyl-Propofol
Status:
Recruiting
Trial end date:
2023-07-31
Target enrollment:
Participant gender:
Summary
Propofol is widely used as an induction agent during general anesthesia. The prevalent
induction dose may be associated with unacceptable cardiovascular instability, especially in
elderly patients.The combination of ketamine and propofol has been shown to balance the
cardiodepressant effects. Esketamine is dextrorotatory structure of ketamine but with
stronger analgesic effects and fewer adverse events.However, there have been no previous
published reports on the use of esketamine combined with propofol during induction. The main
aim of this study was to investigate the haemodynamic effects of esketamine with propofol for
the elderly during induction with LMA( laryngeal mask airway) insertion.