Comparison of Epinephrine-lidocaine Solution and Dexmedetomidine -Lidocaine Solution
Status:
Completed
Trial end date:
2013-05-01
Target enrollment:
Participant gender:
Summary
Scalp infiltration with Epinephrine- containing lidocaine solution is common method for
craniotomy but it may result in transient but significant hypotension in patients undergoing
neurosurgery. Dexmedetomidine, a potent alpha2 adrenoceptor agonist which dose-dependently
reduces arterial blood pressure and heart rate, decreases the hemodynamic and catecholamine
response, and dexmedetomidine has an effect of peripheral vasoconstriction thus it is thus
theologically appropriate for reducing bleeding during scalp incision in craniotomy.
The aim of this study is to compare the effect of dexmedetomidine-lidocaine solution on
hemodynamic response, scalp bleeding to epinephrine-lidocaine solution.