Comparison of Epidural Oxycodone and Epidural Morphine

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The primary objectives of this study are to compare the efficacy of pain relief between epidural oxycodone and epidural morphine for postoperative analgesia after elective caesarean section and to compare the incidence and severity of pruritus. Secondary objectives are to compare other side effects of epidural administered oxycodone and morphine (nausea and vomiting, sedation, respiratory depression) and to investigate the safety and efficacy of epidural oxycodone and epidural morphine after use for postoperative analgesia in caesarean sections.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: KK Women's and Children's Hospital
• Treatments: Analgesics, Opioid; Morphine; Oxycodone

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) physical status 1-2,

• aged between 21 to 50 years undergoing a term elective caesarean section and

• had consented for combined spinal-epidural (CSE) anaesthesia

Exclusion Criteria:

• concurrent opioid therapy,

• contraindications to CSE anaesthesia or any of the study medications,

• a history of pre-existing nausea and vomiting,

• failure to identify intrathecal space at time of anaesthesia,

• inadvertent dural puncture with the epidural needle and

• conversion of regional anaesthesia to general anaesthesia