Comparison of Efficacy and Safety of the Postoperative Analgesia Methods
Status:
Unknown status
Trial end date:
2017-11-01
Target enrollment:
Participant gender:
Summary
An optimal analgesic therapy is very important for postoperative recovery. In recent years,
several studies showed that the prevalence of the moderate to severe pain after craniotomy
ranged from 69 to 87% of patients. In a previous study, the investigators showed that the use
of morphine based patient controlled analgesia prevented moderate to severe postoperative
pain in patients undergoing supratentorial craniotomy. Morphine related side effects such as
sedation, miosis, respiratory depression, nausea and vomiting produce a general reluctance
for their use in neurosurgery. Therefore, all patients were closely observed to detect opioid
related side effects in the intensive care unit for 24 hours following surgery in the
previous study. The Integrated Pulmonary Index (IPI) is a new tool that calculates
respiratory and hemodynamic parameters noninvasively. In the present study the investigators
will use different doses of morphine based PCA and the IPI system to determine more effective
and safer morphine dose for postoperative analgesia following supratentorial craniotomy.