Comparison of Efficacy and Safety of Ezetimibe or Statin Monotherapy to Co-Administration of Both
Status:
Completed
Trial end date:
2007-04-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to compare the percent change in LDL cholesterol induced by
ezetimibe or simvastatin monotherapy and by co-administration of both agents in Black, White
and Hispanic men. Ezetimibe is a drug that blocks sterol absorption and simvastatin blocks
hepatic cholesterol biosynthesis. The hypothesis to be tested is that Blacks are likely to be
more responsive to LDL lowering by ezetimibe than statins because Blacks have a low
production of cholesterol.
Phase:
N/A
Details
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborators:
Donald W. Reynolds Foundation Merck Sharp & Dohme Corp.