Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension
Status:
Terminated
Trial end date:
2007-12-01
Target enrollment:
Participant gender:
Summary
Objective: to assess the effectiveness of pentobarbital and thiopental to control raised
intracranial pressure (ICP), refractory to first level measures, in patients with severe
traumatic brain injury.
Material and methods: prospective, randomized open study to compare the effectiveness between
two treatments: pentobarbital and thiopental. The patients will be selected from those
admitted to the Intensive Care Unit with a severe traumatic brain injury (postresuscitation
Glasgow Coma Scale equal or less than 8 points) and raised ICP (ICP>20 mmHg) refractory to
first level measures according to the Brain Trauma Foundation guidelines. The adverse effects
of both treatments were also collected.