Comparison of EPA and DHA-Rich Fish Oils on Lipoprotein Metabolism In Adults
Status:
Completed
Trial end date:
2019-07-23
Target enrollment:
Participant gender:
Summary
Background:
- Metabolism is what the body does to turn food into energy. Omega-3 fatty acids are
substances found in foods such as cold-water fish and shellfish that are essential for good
health. Researchers want to see the effect of two fatty acids eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA) on metabolism. They may be beneficial to cardiovascular health.
Objective:
- To understand the effects of EPA and DHA on metabolism.
Eligibility:
- Healthy people ages 18 years or above with plasma triglyceride (a type of fat in the blood)
levels of 100 mg/dL or higher
Design:
- The study will last 20 to 24 weeks.
- Participants will have 4 visits to the NIH Clinical Center. These will include:
- Medical history
- Physical Fasting blood and urine tests
- CAVI tests: blood pressure is taken in the arms and legs, and the heart is monitored.
- Participants will take an EPA/DHA dietary supplement. They will take 4 gel capsules, 3
times a day, for 6 or 7 weeks. Then they will not take the capsules for 8 to 10 weeks (a
wash-out period). They will then take the capsules again for 6 or 7 weeks.
- Participants will keep a food journal.