Comparison of Different Helicobacter Pylori Detection Methods in Patients With Chronic Atrophic Gastritis
Status:
Not yet recruiting
Trial end date:
2022-10-30
Target enrollment:
Participant gender:
Summary
As we know，Helicobacter pylori is closely related to many gastrointestinal diseases such as
chronic gastritis, peptic ulcer disease,gastric carcinoma and gastric mucosa-associated
lymphoid tissue lymphoma，as well as extra-digestive diseases such as urticaria and chronic
obstructive pulmonary diseases and so on.The diagnosis of H. pylori infection is based on
invasive methods requiring endoscopy and biopsy(e.g. histology, culture, rapid urease test,
PCR) or on non-invasive methods (e.g. serology, 13C urea breath test, stool antigen
test).Histology has the highest specificity among the others,and also allows us to determine
the underlying disease and perform antibiotic sensitivity testing.Serological tests are
widely available and more appropriate for epidemiological studies, their main weakness for
clinical use is low specificity.The 13C urea breath test is the most accurate method in
patients irrespective of age.Stool antigen testing,as a promising method, is easy to perform,
and its accuracy may be improved by the use of monoclonal antibodies recently proposed for
capturing H. pylori antigen in stool specimen.Sensitivity and specificity, usefulness,and
limitation of tests should be considered for selection of detection methods of H. pylori. Our
objective is to review the current methods that are used for the detection of H. pylori
infection among patients with chronic atrophic gastritis.Except that,patients with Hp
positive will be further treated with 10-day minocycline-based quadruple therapy,to observe
the efficacy and safety of minocycline-based regimen for H.pylori eradication as a first-line
therapy.
Phase:
N/A
Details
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University