Overview

Comparison of Desloratadine Associated With Prednisolone (Tablet)Versus Dexchlorpheniramine Associated With Betamethasone (Tablet) for Adult Persistent Allergic Rhinitis Treatment

Status:
Unknown status
Trial end date:
2014-03-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to evaluate the non-inferiority clinical efficacy of two different drug associations in the treatment of Moderate - Severe Persistent Allergic Rhinitis in Adults.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
EMS
Treatments:
Betamethasone
Betamethasone benzoate
Betamethasone sodium phosphate
Betamethasone Valerate
Betamethasone-17,21-dipropionate
Chlorpheniramine
Desloratadine
Dexchlorpheniramine
Loratadine
Methylprednisolone
Methylprednisolone acetate
Methylprednisolone Hemisuccinate
Prednisolone
Prednisolone acetate
Prednisolone hemisuccinate
Prednisolone phosphate
Criteria
Inclusion Criteria:

- Signed Consent of the patient;

- Clinical diagnosis of moderate - severe persistent allergic rhinitis according to ARIA
classification(Allergic Rhinitis and Its Impact on Asthma);

- Adults aged ≥ 18 years old;

- Evidence of sensitization to aeroallergens in examination (immediate skin tests or
serum specific IgE) in the 12 months prior to inclusion.

Exclusion Criteria:

- Decongestants dependent patients or patients receiving allergen specific
immunotherapy;

- Patients who were in use of oral antihistamines or decongestants in the past 15 days;

- Patients who were treated with systemic corticosteroids in the last month;

- Patients on treatment with monoamine oxidase inhibitors (MAOIs);

- Patients with history of hypersensitivity to any of the formula compounds;

- Patients with any clinically significant disease that in the investigator opinion can
not participate in the study

- Patients who have uncontrolled asthma, chronic sinusitis, drug related rhinitis and
nasal anatomic abnormalities.

- Participation in clinical trial in 30 days prior to study entry;