Comparison of Deep Extubation During Emergence Using Desflurane or Desflurane With Remifentanil in Patients Undergoing General Anesthesia

• Status: Completed
• Trial end date: 2014-03-01
• Target enrollment: 0
• Participant gender: All

Summary

It has been reported that deep extubation can reduce cardiopulmonary complication against endotracheal tube extubation during emergence from general anesthesia. The investigators hypothesized that using desflurane with target controlled infusion of remifentanil is more effective than using desflurane alone during deep extubation. The purpose of this study is to evaluate the effect of remifentanil to prevent respiratory complication (etc. coughing) during emergence from general anesthesia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chung-Ang University Hosptial, Chung-Ang University College of Medicine
• Treatments: Anesthetics; Desflurane; Isoflurane; Remifentanil

Criteria

Inclusion Criteria:

• Age 20-60

• patients undergoing elective surgery take more than an hour

• Under general anesthesia using an LMA

• ASA I,II

Exclusion Criteria:

• Patients on CNS depressants

• Chronic opioid use

• Corticosteroid

• Pregnant patients

• Full stomach

• Morbidly obese (BMI >35kg/m2)

• Hepatitis B

• Hepatitis C

• Coronary artery disease

• Liver disease

• Renal disease

• Seizure disorder

Dropout criteria:

• Need for reintubation due to breath holding

• high ETCO2 during self ventilation (ETCO2>50)

• Surgeon or patient request