Comparison of Cy-Atg vs Flu-Atg for the Conditioning Therapy in Allo-HCT for Adult Aplastic Anemia
Status:
Unknown status
Trial end date:
2016-02-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to reduce the regimen related toxicities and transplantation
related mortality after allogeneic stem cell transplantation in adult acquired aplastic
anemia (AA), the trials of reduced dose of Cy along with fludarabine and ATG were
performed.11-21 The investigators preliminary data of randomized comparison of
cyclophosphamide plus fludarabine versus cyclophosphamide alone in addition to anti-thymocyte
globulin for the conditioning therapy in allogeneic hematopoietic cell transplantation for
bone marrow failure syndrome supports reduced dose of Cy along with fludarabine and ATG.
Conditioning regimen without Cy may reduce RRT because Cy-containing conditioning remains
several RRT such as hemorrhagic cystitis, SOS and graft versus host disease (GvHD). Recently
there were small trials of fludarabine and ATG (Flu-ATG) for the conditioning regimen of
alloHSCT.22-24 These data raised the feasibility of fludarabine and ATG without Cy for
patients with AA.
This new conditioning regimen of Flu-ATG will be compared to standard regimen of Cy- ATG in a
randomized controlled trial.