Overview

Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery

Status:
RECRUITING

Trial end date:
2025-01-25

Target enrollment:

Participant gender:

Summary

Pain, edema and trismus are the most frequent postoperative sequelae to surgical removal of impacted teeth, all of are due to the local inflammatory response. Use of corticosteroids decrease tissue mediators of inflammation and reduce edema. Use of trypsin-chymotrypsin elaborates the enzymes esterase in blood plasma that inhibits inflammation by hydrolytic degradation of the inflammatory peptides.

Phase:

Details

Lead Sponsor:

B.P. Koirala Institute of Health Sciences

Treatments:

Chymotrypsin
chymotrypsin, trypsin drug combination
Dexamethasone