Comparison of Ciprofol-based and Propofol-based Total Intravenous Anesthesia on Postoperative Quality of Recovery

• Status: Not yet recruiting
• Trial end date: 2024-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Ciprofol is a novel 2,6-disubstituted phenol derivatives and is proved have much higher potency and tighter binding toward ɣ-aminobutyric acid type A (GABAA) receptor while maintaining a fast on-set and recovery time compared to propofol. Except lower incidence of hypotension and respiratory depression, it has no injection pain and infusion syndrome compared with propofol. There is no study to investigate overall postoperative functional recovery in patients receiving total intravenous anesthesia (TIVA) using ciprofol yet. However, according to study, early quality of recovery according to QoR-15 score is associated with one-month postoperative complications after elective surgery. Therefore, the purpose of this study is to determine whether there is any difference in the quality of postoperative recovery between ciprofol-based and propofol-based TIVA in elderly patients undergoing gastrointestinal surgery. The QoR-15 questionnaire score, pain, nausea/vomiting, and the frequency of complications are evaluated and compared between the two groups.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Xijing Hospital
• Treatments: Propofol

Criteria

Inclusion Criteria:

• Patients undergoing elective gastrointestinal surgery under endotracheal intubation and general anesthesia

• American Society of Anesthesiologists (ASA) classification: I to III;

• Age ≥ 60 years, BMI < 30 kg/m2;

• Unconscious speech audiovisual impairment or unable to cooperate;

• Informed consent has been signed.

Exclusion Criteria:

• Taking any sedative, opioid, or sleep aid drugs;

• Psychiatric or neurological disorder;

• Allergic to ciprofol, propofol or soy, or a family history of malignant hyperthermia;

• Severe liver and kidney dysfunction;

• Operation duration < 2 hours;

• Plan to the intensive care unit with tracheal catheter;

• Have participated in this study or other clinical studies.