Comparison of Brovavir Versus Acyclovir in the Treatment of Herpes in HIV-Infected Patients
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
To compare the efficacy of oral sorivudine (brovavir) and oral acyclovir for the treatment of
localized herpes zoster in HIV-infected patients.
HIV-infected patients are at high risk for herpesvirus infections, including varicella-zoster
virus ( VZV ) infections, also called shingles. Acyclovir, an approved drug, is widely used
to treat VZV infections in the HIV population. Since no data from controlled studies are
available to define the role of antiviral therapy for VZV infections in HIV-infected
patients, a study is needed to test the relative efficacy of brovavir, an experimental
antiviral drug, versus that of acyclovir.
Phase:
Phase 2
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)