Comparison of Biocompatibility of Plasmapheresis Procedures With Citrate and Heparin Anticoagulation

• Status: Recruiting
• Trial end date: 2022-12-30
• Target enrollment: 0
• Participant gender: All

Summary

Membrane plasmapheresis is one of the methods for treating immune diseases. Plasmapheresis removes autoantibodies and immune complexes, paraproteins, lipoproteins and reduces the concentration of cytokines. In membrane plasmapheresis, plasma is separated from blood cells by a highly permeable membrane. The filtered plasma is then discarded and replaced with replacement fluid. During the procedure, there is an activation of the coagulation system, because of the extracorporeal blood circulation. The anticoagulation during the procedure is therefore necessary.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Medical Centre Ljubljana
• Treatments: Calcium heparin; Citric Acid; Heparin; Sodium Citrate

Criteria

Inclusion Criteria:

• older than 18 years

• an indication for plasma exchange (plasmapheresis) with albumin solution as a replacement solution

Exclusion Criteria:

• contraindication for systemic heparinisation

• acute bleeding

• known active malignancy

• severe infection

• anticoagulant therapy at therapeutic dose