Comparison of Autologous Serum Versus Preservative Free Artificial Tear
Status:
Completed
Trial end date:
2016-03-01
Target enrollment:
Participant gender:
Summary
Dry eye is a significant adverse effect of isotretinoin causing patients to use ophthalmic
medications. For this reason, many patients using isotretinoin are referred to ophthalmology
clinic because of discomfort symptoms. In the literature, there are studies suggesting
superiority of Autologous serum drops regarding effects on ocular surface when compared to
artificial tear. In addition, Autologous serum was also used in several corneal pathologies
with successful outcomes. No data regarding use in the ocular adverse effects of isotretinoin
was found in the literature; however, investigators think that it may be an effective
alternative in the treatment of dry eye developed during isotretinoin use due to positive
effects on ocular surface, epithelial regeneration and anti-inflammatory effect. Autologous
serum can be a choice of ophthalmologists in routine practice by increasing number of
comprehensive studies investigating effectiveness, safety and long-terms effects of
Autologous serum therapy.In this study, it was aimed to investigate dry eye development in
the patients receiving systemic retinoic acid therapy and to compare effectiveness of
Autologous serum and Preservative free artificial tear in the patients with dry eye disease.