Comparison of Autologous Platelet-rich Plasma With Hyaluronic Acid for the Treatment of Osteoarthritis of the Knee Joint

• Status: Completed
• Trial end date: 2015-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the efficacy of platelet-rich plasma versus hyaluronic acid intra-articular injections for the treatment of osteoarthritis of knee joint.

The hypothesis is that PRP intra-articular injection is comparable or even better than hyaluronic acid injection.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Samsung Medical Center
• Treatments: Hyaluronic Acid

Criteria

Inclusion Criteria:

• Patients with osteoarthritis of knee (by American College of Rheumatology Criteria) and Kellgren-Lawrence grade I ~ III

• More than 40 out of 100-mm VAS scale for pain at screening and baseline

• Participant is willing and able to give informed consent for participation in the study

Exclusion Criteria:

• Patients with Hb values < 10 g/dl and platelet values < 100,000/ul

• Patients with a current or medical history of autoimmune disease

• Recent fever ( within 2 weeks) or serious illness

• Local infection at the site of the procedure

• Corticosteroid injection at treatment site within 1 month

• Systematic use of corticosteroids within 2 weeks

• Female participants who are pregnant, lactating or planning pregnancy during the course of the study

• Patients who have been administered with immunosuppressants within the past 6 weeks

• Patients who are enrolled in any other clinical trials within 4 weeks

• Patients who the principal investigator considers inappropriate for participation in the clinical trial for reasons other than those listed above