Comparison of Aprepitant Versus Gabapentin in the Prevention of Delayed Nausea and Vomiting
Status:
Completed
Trial end date:
2007-09-01
Target enrollment:
Participant gender:
Summary
1. To compare the effectiveness of gabapentin (titrated to300mg TID days -2 to 5) with
aprepitant (125mg on day 1 and 80mg on days 2 and 3) in the control of delayed nausea
and vomiting associated with level 3, 4 or 5 emetogenic chemotherapy in patients who
experienced delayed nausea and/or vomiting during their first cycle of chemotherapy.
2. To evaluate and compare the safety profile associated with each anti-emetic regimen.
3. To assess subject satisfaction with anti-emetic therapy.