Comparison of Anesthesia Effects of Sevoflurane and Propofol Combined With Dexmedetomidine in Intraoperative Neuromonitoring During Thyroidectomy

• Status: Active, not recruiting
• Trial end date: 2021-03-31
• Target enrollment: 0
• Participant gender: All

Summary

According to the previous studies, it is reported that the use of sevoflurane in the maintenance of anesthesia may lead to delayed occurrence of positive electromyographic (EMG) signal and lower obtained signal amplitude. In this study, the investigators aimed to investigate the anesthetic effect of sevoflurane combined with dexmedetomidine for neuromonitoring during thyroid surgery. The investigators hypothesize that sevoflurane combined with dexmedetomidine can reduce the movement or spontaneous activity of vocal cords in patients and without affecting the EMG signals.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Affiliated Cancer Hospital & Institute of Guangzhou Medical University
• Treatments: Anesthetics; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• patients scheduled for thyroidectomy under general anesthesia

• American Society of Anesthesiologists (ASA) grade of I or II

• aged 18 to 65 years

• body mass index (BMI) < 32 kg/m2.

Exclusion Criteria:

• patients with RLN or vagus nerve injury were identified preoperatively

• severe cardiovascular, pulmonary, liver and kidney diseases

• history of allergy to narcotic include rocuronium -pregnancy or lactation-

• history or current usage of medication which may interfere neuromuscular transmission;

• family or personal history of malignant hyperthermia

• myasthenia gravis

• potential risk of airway difficulty

• unable to cooperate.