Comparison of Acetaminophen and PRP Therapy for Knee OA
Status:
Completed
Trial end date:
2015-08-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to test whether the platelet-rich plasma (PRP) intra-articular
injection therapy is effective as an alternative treatment option in patients with mild knee
osteoarthritis within a controlled randomized study compared to first line treatment
acetaminophen. The investigators will evaluate patients outcome in level of pain, knee
function and quality of life before the treatment and at 6, 12 and 24 weeks follow up.
The study will be complemented with in vitro experiments of human osteoarthritic cartilage
explants culture (treated with PRP) for histological and gene expression assays.
PRP intra-articular injections therapy is effective in patients with mild knee osteoarthritis
by modifying the biochemical joint environment and cartilage regeneration capability.