Comparison of A Single Dose Combination of Methadone and Morphine With Morphine Alone for Treating Post-operative Pain

• Status: Completed
• Trial end date: 2018-07-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a randomized Phase II study testing the effectiveness of the combination of morphine and methadone versus morphine alone in relieving pain. A second goal is to further evaluate any side effects of the combination of morphine and methadone.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Memorial Sloan Kettering Cancer Center
• Treatments: Analgesics; Methadone; Morphine

Criteria

Inclusion Criteria:

• Retroperitoneal lymph node dissection

• Planned post-operative analgesia with PCA at 1 mg continuous infusion and 1 mg every 10 minutes

• 18 years of age or older

• English-speaking

• Give informed consent to participate in this study

Exclusion Criteria:

• Known hypersensitivity to methadone or morphine

• Patients with past or present history of substance abuse

• Patients with a history of methadone treatment

• Patients with a history of chronic pain requiring daily analgesic use for more than 3 months

• Patients treated with opioids within one month from the scheduled surgery

• Creatinine clearance less than 50 mg/kg (using Cockcroft-Gault Equation).

• Neurologic or psychiatric disease sufficient, in the doctor's opinion, to compromise data collection