Comparison Study of Cefazolin Versus Cefazolin Plus Azithromycin Prophylaxis in Post-Cesarean Endometritis
Status:
Withdrawn
Trial end date:
2014-11-01
Target enrollment:
Participant gender:
Summary
Despite the generalized use of preoperative antibiotic prophylaxis, endometritis remains as
the most frequent post-cesarean delivery complication. This increased morbidity translates
into extended post-partum antibiotic use and prolongation of hospital stay with the
subsequent increase in health care expenses. The current regimen recommended by the American
College of Obstetricians and Gynecologists for cesarean delivery prophylaxis (1st generation
cephalosporins) does not cover for Ureaplasma Urealyticum, a microorganism that has been
associated with an increased risk of endometritis in post-cesarean section patients.
Azithromycin, an antibiotic that has both aerobic and some anaerobic coverage, uniquely
covers Ureaplasma and would be an excellent second antibiotic for cesarean section
chemoprophylaxis. Our hypothesis is that the addition of azithromycin to standard
chemoprophylaxis with cefazolin can effect a 25% reduction of post-cesarean section
endometritis.