Comparison Of The Effects Of Carbetocin And Oxytocin In C-Sectıon
Status:
Not yet recruiting
Trial end date:
2023-06-21
Target enrollment:
Participant gender:
Summary
Obstetric hemorrhage is the most common cause of maternal mortality worldwide and its
incidence is estimated to be approximately 24%. A series of studies has shown that the risk
of serious postpartum hemorrhage decreases with correct and active management in the third
stage of labor. And the routine use of uterotonic agents underlies effective management. It
has been reported that the routine use of uterotonic agents (oxytocin, carbetocin,
ergometrine, etc.) reduces the risk of postpartum bleeding by 40% on average. However, the
uterotonic agent and dose protocol are still unclear. Oxytocin is the most preferred agent
for postpartum hemorrhage prophylaxis after vaginal and cesarean delivery in cases without
risk factors, as it has a rapid onset of effect, does not increase blood pressure, and does
not cause a retained placenta. In cases where oxytocin cannot be used, other agents of choice
are ergot derivatives and misoprostol. The use of carbetocin, a long-acting oxytocin
analogue, is now recommended in the guidelines for risky vaginal deliveries and postpartum
hemorrhage prophylaxis after C-section. Carbetocin also reduces the need for additional
uterotonics. Although carbetocin has been approved for use by the ministry of health, it
still has limited clinical use in Turkey. It is vital for the medical community to have more
experience with using carbetocin, an agent cited in medical guidelines and is also available
in our country, and to share their experiences on academic platforms. This study intends to
investigate oxytocin and carbetocin, which are uterotonic agents used during C-section, in
terms of haemodynamic changes they cause, their effects on the uterine tone and on bleeding
as well as their side effects (flushing, headache, back pain, hypertension and tachycardia,
nausea-vomiting, etc.), to determine if there are any differences between them and share our
insights with the reader.