Comparison Of Surfactant Lung Lavage With Standard Care In The Treatment Of Meconium Aspiration Syndrome
Status:
Completed
Trial end date:
2012-04-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate the role of surfactant lung lavage in the treatment
of meconium aspiration syndrome. Aspiration of meconium into the tracheo-bronchial tree with
the onset of respiration results in meconium aspiration syndrome (MAS). Aspirated meconium
inhibits surfactant function directly and also decreases its synthesis by its toxic effects
on type 2 pneumocytes. There is no specific treatment recommended for meconium aspiration
syndrome. Numerous studies have shown that exogenous surfactant improves outcome in babies
with meconium aspiration. Surfactant replacement alone does not remove meconium from airways
and multiple doses may be required .Therefore an effective therapy to improve outcome is
crucial in treating infants with meconium aspiration. Surfactant Lung lavage has been shown
to be alternative to bolus therapy in treating neonates with meconium aspiration as shown by
many pilot studies. So the investigators have decided to study the role surfactant lung
lavage in the treatment of meconium aspiration syndrome.