Comparison Of Deep Versus Moderate Neuromuscular Blockade on Intra-Operative Blood Loss During Spinal Surgery

• Status: Not yet recruiting
• Trial end date: 2023-03-30
• Target enrollment: 0
• Participant gender: All

Summary

Reduction of intra-operative blood loss

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Assiut University
• Treatments: Rocuronium

Criteria

Inclusion Criteria:

• Age 18- 65 years.

• American Society of Anesthesiologists physical status classification (ASA) I - III

• Patients scheduled for posterior lumbar interbody fusion (2-level or 3-level).

Exclusion Criteria:

• Urgent or emergency case or re-operation.

• History of pre-operative anticoagulant medication or an indication for peri-operative anticoagulant medication.

• ASA classification more than III.

• Age less than 16 years.

• Reduced left and right ventricular function (ejection fraction <40%).

• Previous respiratory disease or a diagnosed neuromuscular disorder.

• Pre-operative dysrhythmia.

• Allergy to neuromuscular blocking agents.

• Family history of malignant hyperthermia.

• Decreased renal function (serum creatinine level more than twice the normal range, urine output <0.5 ml kg/h, glomerular filtration ratio <60 ml/ h).