Comparison Between the Effects of High Doses Statin on Ventricular Remodeling in STEMI Patients
Status:
Completed
Trial end date:
2023-04-01
Target enrollment:
Participant gender:
Summary
STEMI is a serious type of coronary heart disease, which is a major cause of disability and
death. Morphologically the key feature of remodeling is myocyte hypertrophy, myocyte loss
from necrosis or apoptosis, as well as interstitial cell growth especially fibroblast
proliferation leading to myocardial fibrosis .
Elevated serum LDL-cholesterol concentrations play a proatherogenic role by stimulating
inflammation and oxidative processes.
Statins have been documented to retard fibrosis and ventricular hypertrophy by the cessation
of myofibroblast activity. Clinical studies have proven that statins not only regulate lipids
but also improve myocardial fibrosis, regulate cell proliferation and apoptosis, regulate
ventricular remodeling, and protect the myocardium