Comparison Between aPDT and Systemic Doxycycline on Non-surgical Periodontal Therapy in Type 2 Diabetics
Status:
Completed
Trial end date:
2012-10-01
Target enrollment:
Participant gender:
Summary
The objective of this study is to evaluate Photodynamic Therapy (PDT) as adjunct on non
surgical periodontal therapy in patients with type 2 diabetes. A total of 40 individuals will
be selected and divided in two groups. On the treatment stage, the control group (Group C)
will receive standard non surgical periodontal treatment. The Test Group (Group T) will be
treated with PDT as an adjunct to non surgical periodontal treatment. The treatment will be
repeated 4 times in two weeks, followed by dental prophylaxis every 15 days until accomplish
3 months. The follow-up will be done for 6 months. The clinical parameters measured will be:
plaque index, pocket depth, bleeding on probing, relative clinical insertion level and
suppuration. In addition, the evaluation of crevicular fluid volume and the levels of IL-1,
TNF-α, subgingival microbiota by the hybridization DNA-DNA Checkerboard technique. The
investigators expect to find identical or better results for the test group.
Phase:
Phase 3
Details
Lead Sponsor:
University of Sao Paulo
Collaborator:
Fundação de Amparo à Pesquisa do Estado de São Paulo