Comparison Between Two Concentration of Hypertonic Saline in Intestinal Obstruction Surgery
Status:
Unknown status
Trial end date:
2020-02-01
Target enrollment:
Participant gender:
Summary
Background and Rationale :
Perioperative fluid management is a challenging issue in surgical care especially in a
procedure specific model. Recently hypertonic saline (HS) has the advantage of using the
patient's own total body water by drawing interstitial space. Although it still controversial
whether HS is associated with benefits in specific patient populations, particularly with
respect to site of lesion and illness severity; these data provide insight into therapeutic
modalities to curtail ileus formation.
Objectives :
- Measurement of total volume of fluid infused, the need of inotropic or vasopressor to
maintain adequate hemodynamic parameters with assessment of electrolyte disturbances and
S.lactate
- The incidence rate of surgical complications; infection and anastomotic dehiscence
Study population & Sample size :
There were no previous trials comparing the two studied groups of the current trial. We
expected a small standardized effect size of 0.2. Based on this effect size, 25 subjects will
be needed to elicit the difference between the two groups at an alpha level of 0.05 and power
of 0.9 (Whitehead et al; 2016).