Comparison Between Rectal & Sublingual Misoprostol Before Caesarian Section To Reduce Intra & Post-Operative Blood Loss

• Status: Completed
• Trial end date: 2014-02-01
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of the work is to evaluate & compare the effectiveness of rectally administered PGE1 synthetic analogue (misoprostol) 400 microgram versus sublingually administered misoprostol before caesarean section to decrease blood loss during and after the operation.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Misoprostol

Criteria

Inclusion Criteria:

1. Patients booked for elective cesarean section.

2. Singleton pregnancies. 3- Full term pregnancies (GA 37-42 weeks). 4- Patients with only previous one cesarian section

Exclusion Criteria:

1. Primigravida.

2. Blood dyscrasias.

3. Large fibroids.

4. Multiple pregnancies.

5. Overdistended uterus eg. Hydramnios.

6. Pre-eclampsia.

7. Marked maternal anemia (Preoperative hemoglobin < 9 gm/dl).

8. Previous history of PPH.

9. Contraindications to prostaglandin therapy (e.g. history of severe bronchial asthma or allergy to misoprostol.

10. Placenta previa.

11. Contraindication to spinal anesthesia.

12. Previous myomectomy.

13. Previous two or more C.S.