Comparison Between Propofol and Inhalational Anaesthetic Agents on Cardiovascular Outcomes Following Cardiac Surgery

• Status: Recruiting
• Trial end date: 2022-01-31
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this research proposal is to find out whether comparing the two different anaesthetic maintenance techniques (Propofol vs volatile anaesthetics) in adult patients undergoing heart surgery is practical for the anaesthetist treating the patients and whether it is feasible for the research team to recruit patients and follow them up after the operation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: King's College Hospital NHS Trust
• Collaborators: Guy's and St Thomas' NHS Foundation Trust; London School of Hygiene and Tropical Medicine
• Treatments: Anesthetics; Desflurane; Isoflurane; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• Patients (male and female) aged 18 years and above

• Written informed consent to participate

• Patients undergoing Coronary Artery Bypass Graft (CABG) surgery on Cardiopulmonary bypass (CPB) with or without valve surgery

• Additive European System for Cardiac Operative Risk Evaluation (EuroSCORE) of 5 or higher

Exclusion Criteria:

• Pregnant or lactating women

• Allergy to propofol

• Previous diagnosis or suspected malignant hyperthermia

• Patients with a known sensitivity to any of the IMPs or other halogenated anaesthetics

• Concomitant therapy with glibenclamide or nicorandil (medications that may interfere with preconditioning)

• Inclusion in another clinical trial of an investigational medicinal product within the last 3 months.