Comparison Between Low-dose Ketamine Infusion and Intravenous Morphine
Status:
Completed
Trial end date:
2020-06-20
Target enrollment:
Participant gender:
Summary
Ketamine is an antagonist of N-methyl-d-aspartate (NMDA) receptor that not only abolishes
peripheral afferent noxious stimulation, but it may also prevent central sensitization of
nociceptors as shown in animal studies with excellent analgesic property even in
subanesthetic doses. It is readily available and is being used currently, even by
non-Anesthesiologists, to provide "sedation" for minor procedures.(.. Low-dose ketamine
infusion in the perioperative period has shown to produce analgesia and decrease the
requirements of opioid analgesics.. In obstetrics, it is being used as an adjunct to an
inadequately functioning spinal anesthesia for caesarean section, as an induction agent for
cesarean section and also to provide analgesia during labor in intermittent boluses.