Comparison Between Hyperoncotic and Isooncotic Albumin to Support Blood Loss Replacement
Status:
Recruiting
Trial end date:
2023-05-31
Target enrollment:
Participant gender:
Summary
Fluid intravascular replacement is usually performed with either balanced crystalloids or
iso-oncotic colloids, (synthetic colloids, plasma and 5% albumin). Doubts have been raised
about synthetic colloids, and albumin solutions have been used more extensively. Albumin is
the main protein responsible for plasma oncotic pressure and its volume expansion effect. The
mobilization of extravascular fluid by infusing a hyper-oncotic solution like 20% albumin
solution has been shown, causing endogenous fluid recruitment and blood volume expansion.
The primary objective of this study is to compare the effect on plasma volume expansion and
fluid recruitment of 3 different types of fluids (Albumin 5% and Albumin 20% and
Ringer-lactate) during the hemorrhagic phase of the cystectomy procedure.
Secondary objectives are the assessment of the hemodynamic parameters during surgery and the
follow-up of pro-ANP and pro-BNP peptides. Glycocalyx proteins will be followed to evaluate
endothelial wall shedding and microcirculation damages.