Comparison Between Dexmeditomidine, Midazolam and Ketamine as a Sedative to Help Cannula Insertion in Pediatric Patient
Status:
Completed
Trial end date:
2021-02-15
Target enrollment:
Participant gender:
Summary
Background and Objectives: Surgery and hospitalization present a very stressful period for
children and their parents. The induction of anesthesia and cannula insertion may be the only
bad experience a child can remember during his procedure. Pediatric intravenous cannulation
is technically difficult and moreover may cause psychological problems. Sedative
Premedication has a great role in pediatric anesthesia to overcome fear and anxiety and to
facilitate easy separation from their parents. Intranasal approach is safe and painless and
well tolerated by children in addition to a comparable onset of action with the intravenous
approach. Midazolam, dexmedetomidine and ketamine have proved their effectiveness as a
sedative premedication. The objective of the current study was to compare the effectiveness
of administration of intranasal midazolam, dexmedetomidine and ketamine as sedatives to
facilitate and decrease the discomfort of intravenous cannulation before surgery in children
undergoing various surgical procedures. Methods: the patients agreed to participate in the
research were classified into 3 groups. Dexmedetomidine, Midazolam and Ketamine group; each
group received the intranasal drug 30 min before the procedure. Pulse, MAP, oxygen saturation
and sedation score (MOAA/S) baseline and every 10 min. Easiness of venipuncture, parental
separation and any complication encountered were recorded.