Comparison Between Amoxycillin/Clavulanic Acid and Oxacillin/Ceftriaxone for Community Acquired-pneumonia
Status:
Completed
Trial end date:
2009-04-01
Target enrollment:
Participant gender:
Summary
Objective: To compare the clinical effectiveness and hospital costs, the initial empirical
treatment, Oxacillin / Ceftriaxone and Amoxicillin / Clavulanate in children with Community
Acquired Pneumonia (CAP) severe.
Methods: Clinical prospective randomized study in children aged two months to five years of
age with a diagnosis of severe CAP, according to criteria of World Health Organization (WHO),
admitted to the Pediatrics Ward of the Hospital of the Medical School of Botucatu- UNESP. We
excluded children with comorbid disorders (primary and secondary immunodeficiency) with acute
or chronic kidney disease, referred patients receiving antibiotics proposal and history of
allergy to antibiotics proposed. We included 104 children who were randomized into two groups
to receive: Oxacillin / Ceftriaxone IV (GCO, n = 48) and Amoxicillin / Clavulanate IV (GAA, n
= 56). Patients of the GAA, after clinical improvement, has been receiving the same oral
antibiotic, and maintaining clinical stability, were discharged from hospital, the GOC
received any IV treatment. The outcomes analyzed were time to clinical improvement (fever and
tachypnea), duration of oxygen therapy, hospitalization time, need to expand the
antimicrobial spectrum progression to pleural effusion / empyema (DP / E) and hospital costs.
Treatment failure was determined by the need to expand the antimicrobial spectrum after 48
hours of hospitalization.