Comparing the Use of Saline or Saline Plus Gentamycin in Nasal Irrigation to Treat Chronic Sinusitis in Children
Status:
Completed
Trial end date:
2010-03-01
Target enrollment:
Participant gender:
Summary
Healthy children may develop symptoms of chronic sinusitis such as chronic cough, chronic
runny nose, nasal congestion, even headaches. Such symptoms may persist long after the child
gets over other symptoms of a cold and commonly result in the prescription of oral
antibiotics. The purpose of this study is to evaluate whether using saline alone or saline
plus an antibiotic (gentamycin) to irrigate the nose directly once a day for 6 weeks is
effective and safe for the treatment of the above named symptoms. Computerized axial
tomography (CAT) scans and quality of life surveys will be used to compare the health of the
sinuses before and after treatment, and scored to determine which of the two treatments,
saline alone or saline with gentamycin, is more effective in the treatment of this condition.
The study hypothesis is that intranasal saline irrigation will work as well as saline plus
gentamycin, and that majority of the patients will experience significant improvement after a
6 week treatment period.