Overview

Comparing the Efficacy of Periarticular Bone Structure in Patients Treated With Either Tocilizumab or Tumor Necrosis Factor Blockers

Status:
Completed
Trial end date:
2018-03-31
Target enrollment:
Participant gender:
Summary
Comparing the structural effects of TNFi and tocilizumab on the periarticular bone by performing a comprehensive analysis of the periarticular bone changes in RA patients treated with either TNFi or tocilizumab in a longitudinal Setting, using high-resolution peripheral quantitative computed tomography (HR-pQCT), a very sensitive method for visualizing and quantifying bone microstructure in RA patients. Quantitatively assessing the changes of erosions volume, osteophytes size and the area of cortical fenestration in a group of TNFi-treated and a group of tocilizumab- treated RA patients.
Details
Lead Sponsor:
University of Erlangen-Nürnberg Medical School
Treatments:
Adalimumab
Certolizumab Pegol
Etanercept
Golimumab
Infliximab