Comparing the Effects of Conivaptan and Diuretics on Plasma Neurohormones and Renal Blood Flow in Patients With Chronic Congestive Heart Failure

• Status: Unknown status
• Trial end date: 2010-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to compare the effects of conivaptan and diuretics on renal blood flow and neurohormones.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hennepin County Medical Center, Minneapolis
• Collaborator: Astellas Pharma Inc
• Treatments: Conivaptan; Diuretics; Furosemide; Neurotransmitter Agents

Criteria

Inclusion Criteria:

• Have a diagnosis of chronic congestive heart failure of any etiology

• Be between 18-80 years of age

• Able to provide consent

• Have a documented left ventricular ejection fraction within the last year of < 40%

• On a stable dose (no changes within 2 weeks) of 40 mg or greater daily dose of furosemide or its equivalent

• On standard HF therapy medications (ACEI or ARB and beta-blocker unless contraindicated)

• Have an estimated glomerular filtration rate (GFR) of 30 ml/minute or greater (based on the Cockcroft Gault calculation)

• Have a hemoglobin of > 10 grams/dl

• Have a negative urine pregnancy for women of childbearing years only

Exclusion Criteria:

• Acute coronary syndrome within 1 month

• Systolic blood pressure less than or equal to 90 mmHg at time of enrollment

• Poor peripheral venous access

• Severe concomitant disease which deemed by the investigator would render them unsuitable for this trial

• Allergy or contraindication to the use of iothalamate, PAH - Specifically any allergies to iodine or iodine containing products, history of asthma and hay fever which deemed by the investigator would render them unsuitable for this trial