Comparing the Effect of Sitagliptin/Metformin and Metformin in PCOS Patients

• Status: Recruiting
• Trial end date: 2021-07-30
• Target enrollment: 0
• Participant gender: Female

Summary

Investigators will evaluate and compare the efficacy of Sitagliptin/Metformin to metformin and sitagliptin on gdf9 and bmp15 gene expression on PCOS patients undergoing intracytoplasmic sperm injection(ICSI).

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shahid Beheshti University of Medical Sciences
• Treatments: Metformin; Sitagliptin Phosphate

Criteria

Inclusion Criteria:

• subject has clinical or biochemical hyperandrogenic symptoms

• subject has oligo/amenorrhea cycles

Exclusion Criteria:

• Hypersensitivity to metformin

• Hypersensitivity to sitagliptin presence of infertility factors other than anovulation,

• male infertility

• pelvic organic pathologies

• congenital adrenal hyperplasia

• thyroid dysfunction

• Cushing's syndrome

• hyper prolactinemia

• androgen secreting neoplasia

• diabetes mellitus

• consumption of medications affecting carbohydrate metabolism

• consumption hormonal analogues other than progesterone 2 months prior to enrolment in the study

• severe hepatic

• pancreatitis

• kidney diseases

• gallbladder diseases