Overview

Comparing the Effect of Ketamine and Magnesium Sulfate Gargling With Placebo on Post-operative Sore Throat

Status:
Completed
Trial end date:
2021-02-07
Target enrollment:
0
Participant gender:
All
Summary
A prospective randomized double-blind study including patients ASA I-II, aged more than 18 years undergoing surgery under general anesthesia (GA) and endotracheal intubation. Patients were randomized allocated into 2 groups: ketamine group received ketamine gargle (0.5 mg/kg up to 30 ml dextrose water) and magnesium group received magnesium sulfate gargle (20 mg/kg up to 30 mL dextrose water ) 15 minutes before the operation. Our primary outcome is sore throat and the secondary judging criteria are cough, dysphonia and satisfaction. A standardized anesthesia protocol was followed for all patients. After extubation, the patients were asked to grade POST, hoarseness, and cough at 15 min, 1h, and 24 h.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University Tunis El Manar
Treatments:
Ketamine
Magnesium Sulfate
Criteria
Inclusion Criteria:

- age is greater than or equal to 18 years

- ASA class 1 or 2

- patients proposed for elective visceral, orthopedic, oncology, ophthalmologic,
urologic surgery under general anesthesia with orothracheal intubation

Exclusion Criteria:

- known allergy to ketamine or maguisuim sulphate

- ASA 3 and more

- cervical surgery

- difficult intubation planned or history of difficult intubation

- malformation of the O.R.L sphere

- the need for multiple laryngoscopies for orotracheal intubation (≥ 2 attempts);

- the need for a postoperative nasogastric tube.