Comparing Two Treatments for Ovarian Cancer: Standard Chemotherapy Plus Enzastaurin, or Placebo ("Sugar Pill")
Status:
Completed
Trial end date:
2012-07-01
Target enrollment:
Participant gender:
Summary
Participants with ovarian cancer usually get the drugs carboplatin and paclitaxel as initial
treatment. In many participants the tumor will shrink, or even disappear, after treatment
with these drugs. But, unfortunately, the tumor will grow again in many participants. This
trial will try to address the question: Can we delay the time till the tumor grows again by
adding a 3rd drug to the standard therapy? To answer this question, participants will, by
chance, either get the experimental drug enzastaurin or a "dummy pill" (placebo) during the
chemotherapy and for up to 3 years after chemotherapy. Participants and physicians will not
know if a participant gets enzastaurin or placebo (double-blinded trial). After a predefined
time, the treatment will be uncovered, and the number of participants with tumor growth at a
specific time point will be compared between the two treatments.