Comparing Tolerability and Absorption of Racemic and R-lipoic Acid in Progressive Multiple Sclerosis

• Status: Completed
• Trial end date: 2019-01-25
• Target enrollment: 0
• Participant gender: All

Summary

This is a three-week crossover study that will compare how the body absorbs and tolerates two different forms of lipoic acid: R form and racemic form.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rebecca Spain
• Treatments: Thioctic Acid

Criteria

Inclusion Criteria:

• Diagnosis of Progressive Multiple Sclerosis

• 18 years of age or older

• Able to give informed consent and adhere to the study activities

• Able to swallow large oral capsules

Exclusion Criteria:

• Clinical Multiple Sclerosis relapse in the prior 1 year

• Oral or IV steroids in the prior 3 months

• Have taken LA in last 30 days

• Clinically significant kidney disease as determined by the PI including, but not limited to, major kidney disease diagnoses, abnormal laboratory values related to renal function, or other related conditions

• Insulin-dependent diabetes

• Other significant ongoing medical illness that may interfere with study procedures

• Taking oral anticoagulants (e.g. Coumadin). Aspirin, clopidogrel, and dipyridamole are acceptable to take

• Pregnant or breast-feeding

• Any condition which would make the patient, in the opinion of the investigator, unsuitable for the study