Comparing Ticagrelor and Clopidogrel Pharmacodynamics After Thrombolysis
Status:
Withdrawn
Trial end date:
2018-03-01
Target enrollment:
Participant gender:
Summary
This study involves doing platelet function testing in patients who have undergone
fibrinolysis. Fibrinolysis (Use of clot busting medicine in heart attack) is the standard of
care to restore blood flow in blocked arteries as soon as possible after the "Heart attack"
in rural health center where access to cardiac catheterization is one hour away. Fibrinolysis
is done by the emergency room physician in a timely fashion to minimize the damage of the
myocardium. Additionally anti-platelet regimen as adjuvant for patient undergoing
fibrinolysis has been well studied in many trials. In this study investigators will use
clopidogrel or ticagrelor in randomized fashion to evaluate anti- platelet effect by
measuring efficacy in vivo (pharmacodynamics) and blood levels of both drugs
(Pharmacokinetics).