Comparing Standard vs. Modified Reconsolidation Blockade for the Treatment of Psychological Trauma
Status:
Not yet recruiting
Trial end date:
2024-12-01
Target enrollment:
Participant gender:
Summary
The investigators propose to examine a mismatch-based method of reconsolidation blockade for
the treatment of psychological trauma in military personnel and Federal police officers. The
standard reconsolidation blockade treatment (aka Reconsolidation Therapy) involves
reactivating the trauma memory while under the influence of propranolol. The mismatch method
of Reconsolidation Therapy will involve varying the contexts in which the weekly trauma
memory retrieval will occur. This study will involve 10 visits (eligibility assessment,
treatments, and follow-up visits) over a 6-month period for each participant. Treatments will
be conducted once a week for a six-week period where the participant will take a dose of
propranolol (or a placebo pill) 60 minutes prior to memory reactivation. The investigators
hypothesize that reconsolidation blockade treatment will be as effective in treating PTSD
among military personnel and Federal police officers, with the mismatch condition showing
greater symptom improvement.