Comparing Paroxetine and Duloxetine on Cardiovascular Measures

• Status: Completed
• Trial end date: 2007-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This double-blind placebo-controlled trial is designed to test and to compare the cardiovascular profile of paroxetine controlled release (CR) with duloxetine in outpatients with depressive symptoms.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Collaborator: GlaxoSmithKline
• Treatments: Duloxetine Hydrochloride; Paroxetine

Criteria

Inclusion Criteria:

• Depressive symptoms

• Ages 20-60

• In good medical health and not pregnant

Exclusion Criteria:

• Bipolar disorder

• Schizophrenia or other psychotic disorder

• Alcohol or other substance abuse within the last 3 months

• Cognitive impairment

• History of attempted suicide in the past 2 months and who score 4 or more on the suicide item of the MADRS