Comparing Outcomes for Prontosan Versus Normal Saline for Negative Pressure Wound Therapy With Instillation
Status:
Completed
Trial end date:
2016-07-01
Target enrollment:
Participant gender:
Summary
This is a prospective, randomized trial comparing the outcomes for Prontosan versus normal
saline as the solution for negative pressure wound therapy with instillation (NWPTi).
Negative pressure wound therapy (NPWT) is a well established method of treatment for acute
and chronic wounds. The combination of negative pressure with instillation of a solution is a
relatively novel concept that has gained popularity and is currently used nationally and
internationally. NPWTi is the standard of care for our division. Despite the growing use,
there is limited information regarding the selection of the ideal instillation solution. This
is a single site, investigator initiated, NPWTi study comparing the use of Prontosan with
normal saline for the adjunctive treatment of the acutely infected wound that requires
hospital admission. A total of 100 subjects will be included with 50 subjects in each
treatment arm. The outcomes that will be measured are 1) number of operations, 2) length of
hospital stay, 3) % of wounds closed prior to discharge, 4) time to closure prior to
discharge, 5)% remained closed at 30 day follow-up, and 6) reduction of qualitative bacterial
cultures. The results from this study will better characterize the most appropriate use of
NPWTi.