Comparing No Mechanical Bowel Preparation With Oral Antibiotics Alone in Patients Undergoing Elective Colon Surgery

• Status: Recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The REaCT NSQIP will compare oral antibiotics vs. no antibiotics, which are two standards of care treatments for preoperative preparation of the bowel prior to colorectal surgery

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ottawa Hospital Research Institute
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Metronidazole; Neomycin

Criteria

Inclusion Criteria:

• Patients undergoing elective, non-emergency colon, resection surgery or abdominal perineal resection and no other requirements exists for a mechanical bowel preparation (as determined by the operating surgeon)

• 18 years of age or older

• Able to provide oral consent

Exclusion Criteria:

• Contraindication to the oral antibiotics, including allergies or adverse reactions to either metronidazole or neomycin

• Undergoing a rectal resection with a planned anastomosis (these patients will all receive MBP)

• Emergency surgery where no opportunity to administer preoperative oral antibiotics exists

• Requirement for a MBP (i.e. rectal resection with pelvic anastomosis, intraoperative colonoscopy, or at the discretion of the treating surgeon