Comparing Ketamine and Propofol Anesthesia for Electroconvulsive Therapy

• Status: Completed
• Trial end date: 2016-03-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine the effect of ketamine, compared to propofol, when used an an anesthetic agent for electroconvulsive therapy (ECT) in the treatment of major depressive disorder (MDD). We hypothesize that ketamine, compared to propofol, will improve the the symptoms of MDD when used as the anesthetic agent to facilitate ECT. Additionally, we hypothesize the dissociative and cardiovascular effects of ketamine will be minimal.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Saskatchewan
• Collaborators: Royal University Hospital Foundation; Saskatoon Health Region; Schulman Research Award
• Treatments: Anesthetics; Ketamine; Propofol

Criteria

Inclusion Criteria:

• Fulfill the diagnostic criteria for major depression according to the Diagnostic and Statistical Manual of Mental Disorders (most recent edition)

• Failure to respond to at least 2 adequate drug therapies for the current depression episode

• MADRS score of 20 or above (moderate - severe

• ASA physical status classification I to III

Exclusion Criteria:

• Inability to obtain informed consent

• ASA physical status classification IV

• Complication by any serious physical diseases such as cardiovascular disease (including untreated HTN), respiratory disease, cerebrovascular disease, intracranial HTN (including glaucoma), or seizures

• Presence of foreign body (including pacemaker)

• Pregnancy

• Allergies to anesthetics used in study Includes: a) Ketamine b) Propofol c) Eggs d) Egg products e) Soybeans f) Soy products