Comparing Intra-articular Corticosteroid to Intra-articular Ketorolac Knee Injections
Status:
Unknown status
Trial end date:
2017-10-01
Target enrollment:
Participant gender:
Summary
This study will compare the efficacy of intra-articular betamethasone injection to
intra-articular ketorolac injection for symptomatic treatment of knee osteoarthritis in an
equivalence study using a double-blinded, randomized, controlled design. Patients will be
recruited from orthopaedic clinics at St. Luke's University Health Network. A total of 448
patients will be recruited (224 in each group) to receive an administration of an
intra-articular betamethasone or ketorolac injection. The primary outcome is change in pain
as assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
score. Secondary outcomes include Knee Injury and Osteoarthritis Outcome (KOOS) and Knee
Outcome Survey - Activities of Daily Living (KOS-ADL) scores and physical exam findings.
Statistical analyses include repeated measures analysis of variance (ANOVA) (primary outcome)
and selected ANOVA and nonparametric tests as deemed appropriate (secondary outcomes), with p
< .05 denoting significance for all comparisons, and no adjustment for multiple testing.