One of the most common complications after endotracheal intubation is sore throat Lidocaine
jelly or spray, preoperative gargles with licorice or ketamine or I.V steroids used for
prophylaxis against POST are expensive ,and having much more side effects,but nebulized
lidocaine is easily found with decreasing cost ,easily administered ,acts immediately with
short duration ,minimal side effects ,and no term residual side effects.
Nebulized ketamine was found to have a protective effect on allergen-induced airway
inflammatory injury , high airway reactivity ,and decreasing postoperative sore throat (POST)
incidence .
Magnesium sulfate is similar to ketamine in blocking the N-methyl-D-aspartate receptors.