Comparing Efficacy Preoperative Nebulized: Ketamine , Mgspo4 ,and Lidocaine In Attenuating Endotracheal Sore Throat

• Status: Completed
• Trial end date: 2019-03-01
• Target enrollment: 0
• Participant gender: All

Summary

One of the most common complications after endotracheal intubation is sore throat Lidocaine jelly or spray, preoperative gargles with licorice or ketamine or I.V steroids used for prophylaxis against POST are expensive ,and having much more side effects,but nebulized lidocaine is easily found with decreasing cost ,easily administered ,acts immediately with short duration ,minimal side effects ,and no term residual side effects.

Nebulized ketamine was found to have a protective effect on allergen-induced airway inflammatory injury , high airway reactivity ,and decreasing postoperative sore throat (POST) incidence .

Magnesium sulfate is similar to ketamine in blocking the N-methyl-D-aspartate receptors.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Zagazig University
• Treatments: Ketamine; Lidocaine; Magnesium Sulfate; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Patient acceptance.

• Age (21-45) years old.

• American Society of Anesthesiologists (ASA) I / II

• elective surgery of approximately 2-3h duration needing endotracheal intubation

• Patient With BMI(Body Mass Index)(25-30)

Exclusion Criteria:

• Patient refusal.

• Altered mental status.

• History of allergy to drugs in the study

• .Patients with history of pervious sore throat

• using steroids or NSAIDs,with asthma

• neuromuscular disease

• , Mallampati grade>2, with >2 attempts of intubations,

• underlying neck ,and laparoscopic surgeries,

• pregnant women.